Skelettmuskeladaptation: Der Grundbaustein für die Modellierung neuromuskulärer Erkrankungen und die Vorhersage von muskulären Defiziten (Identifikation, Homogenisierung, Verifizierung und Integration)

PIs: Prof. Oliver Röhrle, Dr. Ates

@article{Keles2022,

title = {Botulinum Toxin Intervention in Cerebral Palsy-Induced Spasticity Management: Projected and Contradictory Effects on Skeletal Muscles },

author = {Cemre Su Kaya Keles and Filiz Ates},

editor = {Toxins},

url = {https://www.mdpi.com/2072-6651/14/11/772},

doi = {https://doi.org/10.3390/toxins14110772},

year  = {2022},

date = {2022-11-08},

urldate = {2022-11-08},

journal = {Toxins},

volume = {14},

issue = {11},

pages = {772},

abstract = {Spasticity, following the neurological disorder of cerebral palsy (CP), describes a pathological condition, the central feature of which is involuntary and prolonged muscle contraction. The persistent resistance of spastic muscles to stretching is often followed by structural and mechanical changes in musculature. This leads to functional limitations at the respective joint. Focal injection of botulinum toxin type-A (BTX-A) is effectively used to manage spasticity and improve the quality of life of the patients. By blocking acetylcholine release at the neuromuscular junction and causing temporary muscle paralysis, BTX-A aims to reduce spasticity and hereby improve joint function. However, recent studies have indicated some contradictory effects such as increased muscle stiffness or a narrower range of active force production. The potential of these toxin- and atrophy-related alterations in worsening the condition of spastic muscles that are already subjected to changes should be further investigated and quantified. By focusing on the effects of BTX-A on muscle biomechanics and overall function in children with CP, this review deals with which of these goals have been achieved and to what extent, and what can await us in the future.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{klotz2021investigating,

title = {Investigating the spatial resolution of EMG and MMG based on a systemic  multi-scale model},

author = {Thomas Klotz and Leonardo Gizzi and Oliver R\"{o}hrle},

editor = {Springer},

url = {https://link.springer.com/article/10.1007/s10237-022-01572-7

https://rdcu.be/dpxtQ},

doi = {https://doi.org/10.48550/arXiv.2108.05046},

year  = {2022},

date = {2022-04-20},

urldate = {2022-01-01},

journal = {Biomechanics and Modeling in Mechanobiology},

volume = {21},

pages = {983-997},

abstract = {While electromyography (EMG) and magnetomyography (MMG) are both methods to measure the electrical activity of skeletal muscles, no systematic comparison between both signals exists. Within this work, we propose a systemic in silico model for EMG and MMG and test the hypothesis that MMG surpasses EMG in terms of spatial selectivity. The results show that MMG provides a slightly better  spatial selectivity than EMG when recorded directly on the muscle surface. However, there is a remarkable difference in spatial selectivity for non-invasive surface measurements. The spatial selectivity of the MMG 

components aligned with the muscle fibres and normal to the body surface outperforms the spatial selectivity of surface EMG. Particularly, for the MMG's normal-to-the-surface component the influence of  subcutaneous fat is minimal. Further, for the first time, we analyse the contribution of different structural components, i.e., muscle fibres from different motor units and the extracellular space, to the measurable biomagnetic field. Notably, the simulations show that the normal-to-the-surface MMG component, the contribution from volume currents in the extracellular space and in surrounding inactive 

tissues is negligible. Further, our model predicts a surprisingly high contribution of the passive muscle fibres to the observable magnetic field.},

note = {cite arxiv:2108.05046Comment: Preprint, Submitted to Biomechanics and Modeling in Mechanobiology},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{hessenthaler2022time,

title = {Time-periodic steady-state solution of fluid-structure interaction and cardiac flow problems through multigrid-reduction-in-time},

author = {Andreas Hessenthaler and Robert D Falgout and Jacob B Schroder and Adelaide Vecchi and David Nordsletten and Oliver R\"{o}hrle},

doi = {https://doi.org/10.1016/j.cma.2021.114368},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Computer Methods in Applied Mechanics and Engineering},

volume = {389},

pages = {114368},

publisher = {Elsevier},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{gizzi2021editorial,

title = {Editorial: Somatosensory Integration in Human Movement: Perspectives for Neuromechanics, Modelling and Rehabilitation},

author = {Leonardo Gizzi and Ivan Vujaklija and Massimo Sartori and Oliver R\"{o}hrle and Giacomo Severini},

url = {https://doi.org/10.3389%2Ffbioe.2021.725603},

doi = {10.3389/fbioe.2021.725603},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Front. Bioengineering and Biotechnology, Sec. Bionics and Biomimetics },

volume = {9},

publisher = {Frontiers Media SA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bleiler2021,

title = {Tangent second-order homogenisation estimates for incompressible hyperelastic composites with fibrous microstructures and anisotropic phases},

author = {Christian Bleiler and Pedro Ponte Casta\~{n}eda and Oliver R\"{o}hrle},

url = {https://doi.org/10.1016/j.jmps.2020.104251},

doi = {10.1016/j.jmps.2020.104251},

issn = {0022-5096},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Journal of the Mechanics and Physics of Solids},

volume = {147},

pages = {104251},

keywords = {},

pubstate = {published},

tppubtype = {article}

}