The aim of this Priority Programme is to co-design robust, computational, continuum-biomechanicalmodels by developing new methods combining research in modelling, numerics and medical applications. The focus hereby is on models of active biological systems in the human organism, to advance methods that can later be integrated within a clinical environment and to define the interfaces between model and clinical application. The Priority Programme, however, does not aim to establish the transfer of the models into the clinic via clinical trials. The programme will concentrate on coupling strategies for “active” biological systems. The definition of “active” refers to systems that experience a change of state due to physical, chemical, and/or biological phenomena or stimuli. Examples are metabolicprocesses, growth and remodelling, or electrical stimulation.