SPP2311

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Fluid-Structure-Interaction Modeling of the Heart Hemodynamics using Statistical Shape Models

PIs: Leonid Goubergrits, Katharina Vellguth, Titus Kühne, Fabian Barbieri

Workflow from medical image data to surface representation for computational fluid dynamics simulations

Aim:

The project develops a comprehensive simulation framework for personalized analysis of heart diseases. Coupling advanced numerical models, it integrates clinical data to simulate patient-specific conditions and outcomes, aiding in research, decision support, and treatment planning.

Comparison of intracardiac hemodynamics before and after surgical ventricular restoration

Description:

For the diagnosis and treatment of heart diseases, in silico medicine plays an increasingly important role. In the first funding period of our project in the SPP2311 program, we successfully developed a set of computational models to investigate clinically decisive hemodynamic parameters, including a verified image-based prescribed-motion fluid-structure-interaction (FSI) approach, combined with statistical shape models (SSM) and a lumped element model (LEM).

In the second project phase, we will extend, refine, and couple the existing models to obtain a comprehensive methodological framework that allows robust representation of individual patient conditions and reliable simulation of biomarkers for clinically relevant heart diseases. The FSI approach will be complemented by important structural parameters, namely myocardial contraction, global longitudinal strains, and heart valve dynamics. For this purpose, the SSM and LEM will be employed to enhance and complement clinical real-world data and provide boundary conditions for the biomechanical simulations. Close cooperation between engineers and clinicians will ensure the addressing of relevant clinical needs and the evaluation of simulated results with respect to clinical real-world data. Prospective data of healthy volunteers and phantom measurements will be acquired for methodological development and validation. Subsequently, retrospective patient data of pathological cases will be used to show clinical applicability. The framework will enable us to approach individual treatment planning by creating a personalized baseline model for a specific dataset in a largely standardized and automated manner. The baseline model can be used to simulate altered patient states, which are either not measurable in clinical routine, such as a post-operative treatment outcome, or imply additional risk to the patient, like stress testing. Both baseline and altered patient states can be simulated based on all common image modalities in cardiology, emphasizing our framework’s generalizability.

The technical outcome of this project will be a validated methodological framework with robust coupling and flexible combination of the modeling modules (LEM, FSI, SSM), covering simulations of the circulation, hemodynamics, structure, and anatomical features with the possibility to complement missing clinical data. The expected results on the clinical side comprise the applicability of the methodological framework to research different clinical questions and as treatment planning tools and for decision support applicable to different sources of clinical data.

Involved Institutions:

Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany
Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Berlin, Germany
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Applicants:

Prof. Dr.-Ing. Leonid Goubergrits

Prof. Dr.-Ing. Leonid Goubergrits

Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany
Dr.-Ing. Katharina Vellguth

Dr.-Ing. Katharina Vellguth

Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany
Prof. Dr. med. Titus Kühne

Prof. Dr. med. Titus Kühne

Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany
Dr. med univ. Fabian Barbieri, Ph.D

Dr. med univ. Fabian Barbieri, Ph.D

Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Berlin, Germany
M. Sc. Lukas Obermeier

M. Sc. Lukas Obermeier

Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany
M. Sc. Moritz Wiegand

M. Sc. Moritz Wiegand

Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany

Publications

94 Einträge « 1 von 2 »

2024

Spitz, Iam Lena; Korte, Jana; Gaidzik, Franziska; Larsen, Naomi; Preim, Bernhard; Saalfeld, Sylvia

Assessment of intracranial aneurysm neck deformation after contour deployment Artikel

In: International Journal of Computer Assisted Radiology and Surgery, Bd. 1, S. 1:8, 2024.

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Manjunatha, K.; Ranno, A.; Shi, J.; Schaaps, N.; Florescu, R.; Nilcham, P.; Cornelissen, A.; Behr, M.; Reese, S.

In Silico Reproduction of the Pathophysiology of In-Stent Restenosis Unveröffentlicht

2024.

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Manjunatha, K.; Ranno, A.; Shi, J.; Schaaps, N.; Florescu, R.; Nilcham, P.; Cornelissen, A.; Behr, M.; Reese, S.

In Silico Reproduction of the Pathophysiology of In-Stent Restenosis Unveröffentlicht

2024.

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Danesini, Paolo Carlo; Heim, Maximilian; Tomalka, André; Siebert, Tobias; Ates, Filiz

Endomysium determines active and passive force production in muscle fibers Artikel

In: Journal of Biomechanics, Bd. Volume 168, Ausg. May 2024, 2024.

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Maier, Benjamin; Göddeke, Dominik; Huber, Felix; Klotz, Thomas; Röhrle, Oliver; Schulte, Miriam

OpenDiHu: An efficient and scalable framework for biophysical simulations of the neuromuscular system Artikel

In: Journal of Computational Science, Ausg. 79, S. 102291, 2024, ISBN: 1877-7503.

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Gaidzik, Franziska; Korte, Jana; Saalfeld, Sylvia; Janiga, Gabor; Berg, Philipp

Image-based Hemodynamic Simulations for Intracranial Aneurysms – The Impact of Complex Vasculatures Artikel

In: International Journal of Computer Assisted Radiology and Surgery, Bd. 19, Ausg. 4, S. 687-697, 2024.

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Homs-Pons, Carme; Lautenschlager, Robin; Schmid, Laura; Ernst, Jennifer; Göddeke, Dominik; Röhrle, Oliver; Schulte, Miriam

Coupled simulations and parameter inversion for neural system and electrophysiological muscle models Artikel

In: GAMM-Mitteilungen, 2024.

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Gerhäusser, Steffen; Lambers, Lena; Mandl, Luis; Franquinet, Julian; Ricken, Tim; König, Matthias

Simulation of zonation-function relationships in the liver using coupled multiscale models: Application to drug-induced liver injury Artikel

In: [PrePrint], bioRxiv, 2024.

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Stahl, Janneck; McGuire, Laura Stone; Rizko, Mark; Saalfeld, Sylvia; Berg, Philipp; Alaraj, Ali

Are hemodynamics responsible for inflammatory changes in venous vessel walls? A quantitative study of wall-enhancing intracranial arteriovenous malformation draining veins Artikel

In: Journal of Neurosurgery, 2024.

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Obermeier, Lukas; Wiegand, M.; Hellmeier, F.; Manini, C.; Kuehne, Titus; Goubergrits, Leonid

Verification Study of In Silico Computed Intracardiac Blood Flow With 4D Flow MRI Artikel

In: IEEE Transactions on Biomedical Engineering, Bd. 71, Ausg. 9, S. 2568 - 2579, 2024.

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Ates, Filiz; Roehrle, Oliver

Experiments meet simulations: Understanding skeletal muscle mechanics to address clinical problems Artikel

In: GAMM Mitteilungen, Bd. 2024, 2024.

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Schwarting, Julian; Holzberger, Fabian; Muhr, Markus; Renz, Martin; Boeckh-Behrens, Tobias; Wohlmuth, Barbara; Kirschke, Jan

Numerical simulation of individual coil placement – A proof-of-concept study for the prediction of recurrence after aneurysm coiling Artikel

In: [PrePrint], arXiv, 2024.

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Duswald, Tobias; Keith, Brendan; Lazarov, Boyan; Petrides, Socratis; Wohlmuth, Barbara

Finite elements for Matérn-type random fields: Uncertainty in computational mechanics and design optimization Artikel

In: [PrePrint], arXiv, 2024.

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Han, Mertcan; Yildiz, Erdost; Bozuyuk, Ugur; Aydin, Asli; Yu, Yan; Bhargava, Aarushi; Karaz, Selcan; Sitti, Metin

Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound Artikel

In: Nature Communications, Bd. 15, Ausg. 1, S. 2013, 2024.

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Lambers, Lena; Waschinsky, Navina; Schleicher, Jana; König, Matthias; Tautenhahn, Hans-Michael; Albadry, Mohamed; Dahmen, Uta; Ricken, Tim

Quantifying Fat Zonation in Liver Lobules: An Integrated Multiscale In-silico Model Combining Disturbed Microperfusion and Fat Metabolism via a Continuum-Biomechanical Bi-scale, Tri-phasic Approach Artikel

In: Biomechanics and Modeling in Mechanobiology, 2024.

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Thormann, Maximilian; Stahl, Janneck; Marsh, Laurel; Saalfeld, Sylvia; Sillis, Nele; Ding, Andreas; Mpotsaris, Anastasios; Berg, Philipp; Behme, Daniel

Computational Flow Diverter Implantation—A Comparative Study on Pre-Interventional Simulation and Post-Interventional Device Positioning for a Novel Blood Flow Modulator Artikel

In: Fluids, Bd. 9, Ausg. 3, Nr. 55, 2024.

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Villota-Narvaez, Yesid; Bleiler, Christian; Roehrle, Oliver

Data sharing in modeling and simulation of biomechanical systems in interdisciplinary environments Artikel

In: GAMM Mitteilungen, Bd. 47, Ausg. 2, 2024.

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Horvat, Medeea; Lunowa, Stephan B.; Sytnyk, Dmytro; Wohlmuth, Barbara

A lattice Boltzmann method for non-Newtonian blood flow in coiled intracranial aneurysms Artikel

In: [PrePrint], arXiv, 2024.

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Swiatek, Vanessa M; Amini, Amir; Ortuño, Celina E Sandalcioglu; Spitz, Lena; Hartmann, Karl; Rashidi, Ali; Stein, Klaus-Peter; Saalfeld, Sylvia; Sandalcioglu, I Erol; Neyazi, Belal

Unveiling rupture risk and clinical outcomes in midline aneurysms: A matched cohort analysis investigating the impact of localization within the anterior or posterior circulation Artikel

In: Neurosurgical Review, Bd. 47, Ausg. 76, 2024.

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Holzberger, Fabian; Muhr, Markus; Wohlmuth, Barbara

A Comprehensive Numerical Approach to Coil Placement in Cerebral Aneurysms: Mathematical Modeling and In Silico Occlusion Classification Artikel

In: [PrePrint], arXiv, 2024.

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Frank, Martin; Holzberger, Fabian; Horvat, Medeea; Kirschke, Jan; Mayr, Matthias; Muhr, Markus; Nebulishvili, Natalia; Popp, Alexander; Schwarting, Julian; Wohlmuth, Barbara

Numerical simulation of endovascular treatment options for cerebral aneurysms Artikel

In: [PrePrint], arXiv, 2024.

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König, Matthias

Python utilities for porous media analysis and visualization Online

Zenodo, (Hrsg.): 2024.

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Tautenhahn, Hans-Michael; Ricken, Tim; Dahmen, Uta; Mandl, Luis; Bütow, Laura; Gerhäusser, Steffen; Lambers, Lena; Chen, Xinpei; Lehmann, Elina; Dirsch, Olaf; König, Matthias

SimLivA–Modeling ischemia-reperfusion injury in the liver: A first step towards a clinical decision support tool Artikel

In: GAMM-Mitteilungen e202370003, 2024.

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Obermeier, Lukas; Korte, Jana; Vellguth, Katharina; Barbieri, Fabian; Hellmeier, Florian; Berg, Philipp; Goubergrits, Leonid

Inter-model and inter-modality analysis of left ventricular hemodynamics: comparative study of two CFD approaches based on TTE and MRI Artikel

In: GAMM-Mitteilungen, 2024.

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Schmid, Laura; Klotz, Thomas; Röhrle, Oliver; Powers, Randall K.; Negro, Francesco; Yavuz, Utku Ş.

Postinhibitory excitation in motoneurons Artikel

In: PLOS Computational Biology, Bd. 20, Ausg. 1, 2024.

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Korte, Jana; Marsh, Laurel M. M.; Saalfeld, Sylvia; Behme, Daniel; Aliseda, Alberto; Berg, Philipp

Fusiform versus Saccular Intracranial Aneurysms—Hemodynamic Evaluation of the Pre-Aneurysmal, Pathological, and Post-Interventional State Artikel

In: Journal of Clinical Medicine, Bd. 13, Ausg. 2, Nr. 551, S. 1-14, 2024.

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Ranno, A.; Manjunatha, K.; Glitz, A.; Schaaps, N.; Reese, S.; Vogt, F.; Behr, M.

In-silico Analysis of Hemodynamic Indicators in Idealized Stented Coronary Arteries for Varying Stent Indentation Unveröffentlicht

2024.

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Gerach, Tobias; Loewe, Axel

Differential effects of mechano-electric feedback mechanisms on whole-heart activation, repolarization, and tension Artikel

In: The Journal of Physiology, 2024.

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Korte, Jana; Klopp, Ehlar Sophie; Berg, Philipp

Multi-Dimensional Modeling of Cerebral Hemodynamics: A Systematic Review Artikel

In: Bioengineering, Bd. 11, Ausg. 1, S. 1-24, 2024.

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Fröhlich, Jonathan; Gerach, Tobias; Krauß, Jonathan; Loewe, Axel; Stengel, Laura; Wieners, Christian

Numerical evaluation of elasto-mechanical and visco-elastic electro-mechanical models of the human heart Artikel

In: GAMM Mitteilungen, Bd. 46, Ausg. 2, 2024, ISSN: 1522-2608.

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Yildiz, Erdost; Han, Mertcan; Werneck, Linda; Keip, Marc-Andre; Sitti, Metin; Ortiz, Michael

Experimental model for strain-induced mechanical neurostimulation on human progenitor neurons Artikel

In: Science Communications World Wide, 2024.

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2023

Gjerde, Ingeborg G.; Kuchta, Miroslav; Rognes, Marie E.; Wohlmuth, Barbara

Directional flow in perivascular networks: Mixed finite elements for reduced-dimensional models on graphs Artikel

In: [PrePrint], arXiv, 2023.

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Albadry, Mohamed; Kuettner, Jonas; Grzegorzewski, Jan; Dirsch, Olaf; Kindler, Eva; Klopfleisch, Robert; Liska, Vaclav; Moulisova, Vladimira; Nickel, Sandra; Palek, Richard; Rosendorf, Jachym; Saalfeld, Sylvia; Settmacher, Utz; Tautenhahn, Hans-Michael; König, Matthias; Dahmen, Uta

Cross-Species Variability in Lobular Geometry and Cytochrome P450 Hepatic Zonation: Insights into CYP1A2, CYP2E1, CYP2D6 and CYP3A4 Artikel

In: [PrePrint], bioRxiv, 2023.

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Holzberger, Fabian; Kirschke, Jan; Muhr, Markus; Nebulishvili, Natalia; Schwarting, Julian; Wohlmuth, Barbara

Breaking Blood Flow with Wires in Aneurysm Coiling Treatment Simulations Online

SIAM, News (Hrsg.): 2023, besucht am: 19.12.2023.

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Manjunatha, K.; Schaaps, N.; Behr, M.; Vogt, F.; Reese, S.

Computational Modeling of In-Stent Restenosis: Pharmacokinetic and Pharmacodynamic Evaluation Artikel

In: Computers in Biology and Medicine, Ausg. 167, 2023.

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Azhdari, Mohammad; Seyedpour, Seyed Morteza; Lambers, Lena; Tautenhahn, Hans-Michael; Tautenhahn, Franziska; Ricken, Tim; Rezazadeh, Ghader

Non-local three phase lag bio thermal modeling of skin tissue and experimental evaluation Artikel

In: Heat and Mass Transfer (149), 2023.

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Korte, Jana; Gaidzik, Franziska; Larsen, Naomi; Schütz, Erik; Damm, Timo; Wodarg, Fritz; Hövener, Jan-Bernd; Jansen, Olav; Janiga, Gábor; Berg, Philipp; Pravdivtseva, Mariya S

In vitro and in silico assessment of flow modulation after deploying the Contour Neurovascular System in intracranial aneurysm models Artikel

In: Journal of NeuroInterventional Surgery, 2023.

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Mandl, Luis; Mielke, André; Seyedpour, Seyed Morteza; Ricken, Tim

Affine transformations accelerate the training of physics-informed neural networks of a one-dimensional consolidation problem Artikel

In: Nature Scientific Reports, 2023.

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Stahl, Janneck; Kassem, Leheng; Behme, Daniel; Klebingat, Stefan; Saalfeld, Sylvia; Berg, Philipp

Fabrication of flexible intracranial aneurysm models using stereolithography 3D printing Artikel

In: Current Directions in Biomedical Engineering, Bd. 9, Ausg. 1, S. 395-389, 2023.

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Korte, Jana; Groschopp, Paula; Berg, Philipp

Resolution-based comparative analysis of 4D-phase-contrast magnetic resonance images and hemodynamic simulations of the aortic arch Artikel

In: Current Directions in Biomedical Engineering, Bd. 9, Ausg. 1, S. 650-653, 2023.

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Werneck, Linda; Han, Mertcan; Yildiz, Erdost; Keip, Marc-André; Sitti, Metin; Ortiz, Michael

A Simple Quantitative Model of Neuromodulation. Part I: Ion Flow Through Neural Ion Channels Artikel

In: Biological Physics, 2023.

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Sveric, Krunoslav Michael; Cansız, Barış; Winkler, Anna; Ulbrich, Stefan; Ende, Georg; Heidrich, Felix; Kaliske, Michael; Linke, Axel; Jellinghaus, Stefanie

Accuracy of Devereaux and Teichholz formulas for left ventricular mass calculation in different geometric patterns: comparison with cardiac magnetic resonance imaging Artikel

In: Scientific reports, Bd. 13, 2023.

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Korte, Jana; Voß, Samuel; Janiga, Gábor; Beuing, Oliver; Behme, Daniel; Saalfeld, Sylvia; Berg, Philipp

Is accurate lumen segmentation more important than outlet boundary condition in image-based blood flow simulations for intracranial aneurysms? Artikel

In: Cardiovascular Engineering and Technology, Bd. 14, Ausg. 5, S. 617–630, 2023.

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Maheshvare, M. Deepa; Raha, Soumyendu; König, Matthias; Pal, Debnath

A pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell Artikel

In: Frontiers in Endocrinology, 2023.

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Cornelissen, A.; Florescu, R. A.; Reese, S.; Behr, M.; Ranno, A.; Manjunatha, K.; Schaaps, N.; Böhm, C.; Liehn, E. A.; Zhao, L.; Nilcham, P.; Milzi, A.; Schröder, J.; Vogt, F. J.

In-Vivo Assessment of Vascular Injury for the Prediction of In-Stent Restenosis Artikel

In: International Journal of Cardiology, Ausg. 388, 2023.

Abstract | Links | BibTeX

König, Matthias

Hepatocyte model of ischemia reperfusion injury (IRI) Online

Zenodo, (Hrsg.): 2023, besucht am: 30.06.2023.

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Lee, Yongjae; Cansız, Barış; Kaliske, Michael

A multiphysical computational model of myocardial growth adopted to human pathological ventricular remodelling Artikel

In: 2023.

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Haggie, Lysea; Schmid, Laura; Röhrle, Oliver; Besier, Thor; McMorland, Angus; Saini, Harnoor

Linking cortex and contraction—Integrating models along the corticomuscular pathway Artikel

In: Frontiers in Physiology, Sec. Computational Physiology and Medicine, Ausg. Vol 14-2023, 2023.

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Simeon, Bernd

Die Macht der Computermodelle. Quellen der Erkenntnis oder digitale Orakel? Buch

1, Springer Berlin, Heidelberg, 2023, ISBN: 978-3-662-66298-4.

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Stahl, Janneck; Marsh, Laurel Morgan Miller; Thormann, Maximilian; Ding, Andreas; Saalfeld, Sylvia; Behme, Daniel; Berg, Philipp

Assessment of the Flow-Diverter Efficacy for Intracranial Aneurysm Treatment Considering Pre- and Post-Interventional Hemodynamics Artikel

In: Computers in Biology and Medicine, Bd. 156, Ausg. 106720, 2023.

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94 Einträge « 1 von 2 »