SPP2311

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Coupled analysis of active biological processes for meniscus tissue regeneration - Experiments, statistical data processing, and data-informed in-silico modeling

PIs: Bernd Simeon, Christina Surulescu, Claudia Redenbach, Andreas Seitz

Aim:

The project deals with the modeling, simulation and experimental validation of meniscus tissue regeneration and the involved phenomena on cell and tissue level, based on a non-woven scaffold that is colonized by stem cells.

Description:

Meniscal lesions are among the most common injuries of the knee joint. While tears in the vascularized, outer region of the meniscus can be treated by different suture techniques with good clinical outcomes, tears in the inner, avascular zone have only limited regeneration potential and result in partial or even total meniscectomy and a high risk of chondral damage that finally might end up in premature osteoarthritis. There is, thus, a strong need for an alternative treatment. Although artificial tissues such as polyurethane or allogenic collagen implants have been introduced in recent years as replacement materials, an adequate and durable meniscal replacement is still missing. Our overall goal is thus the development of a regenerative approach where an artificial scaffold is seeded with mesenchymal stem cells that differentiate into chondrocytes and build up a stable collagen structure. Patient-specific data of real menisci serve as target parameters for our interdisciplinary investigations. While we have made great strides towards this goal in the still running first project phase, there are several challenging issues ahead that can only be addressed in a long-term study and a corresponding second project phase. More specifically, the proposed second project phase will advance the present mathematical models, mainly diffusion-reaction-advection equations with mechanical coupling terms, their numerical simulation, and the experimental cell culturing framework to a new level. There, improvements of the in-vitro experiment can be identified and derived from exploration of the in-silico model , and the experiments as well as quantitative image analysis enable in turn a more detailed and data-informed mathematical description. Control variables in this regard are not only the biological and chemical processes, but also characteristic properties of the scaffold geometry. By expanding the experimental studies and the computational model to patient-specific meniscus tissues, we propose to create a hypothetical ex-vivo framework that can provide insight into the relevant processes after an implantation with artificial replacement tissues. Our proposal combines mathematical modeling on multiple scales for a new problem class, numerical simulation in space and time with emphasis on model order reduction and parameter identification, and advanced in-vitro experiments with artificial scaffolds and native meniscus tissues. Additional expertise from quantitative image analysis strengthens our interdisciplinary approach, yielding important new data and also carrying the potential for scaffold design. Summarizing, the major outcome of this project will set up the rationale for the future design of regenerative meniscus replacement material.

Involved Institutions:

RPTU Kaiserslautern-Landau, Dept. of Mathematics
Universität Ulm, Institute of Orthopaedic Research and Biomechanics

Applicants:

Bernd Simeon

Bernd Simeon

RPTU Kaiserslautern-Landau, Dept. of Mathematics
Christina Surulescu

Christina Surulescu

RPTU Kaiserslautern-Landau, Dept. of Mathematics
Claudia Redenbach

Claudia Redenbach

RPTU Kaiserslautern-Landau, Dept. of Mathematics
Andreas Seitz

Andreas Seitz

Universität Ulm, Institute of Orthopaedic Research and Biomechanics
Henry Jäger

Henry Jäger

RPTU Kaiserslautern-Landau, Dept. of Mathematics

Publications

94 Einträge « 1 von 2 »

2024

Spitz, Iam Lena; Korte, Jana; Gaidzik, Franziska; Larsen, Naomi; Preim, Bernhard; Saalfeld, Sylvia

Assessment of intracranial aneurysm neck deformation after contour deployment Artikel

In: International Journal of Computer Assisted Radiology and Surgery, Bd. 1, S. 1:8, 2024.

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Manjunatha, K.; Ranno, A.; Shi, J.; Schaaps, N.; Florescu, R.; Nilcham, P.; Cornelissen, A.; Behr, M.; Reese, S.

In Silico Reproduction of the Pathophysiology of In-Stent Restenosis Unveröffentlicht

2024.

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Manjunatha, K.; Ranno, A.; Shi, J.; Schaaps, N.; Florescu, R.; Nilcham, P.; Cornelissen, A.; Behr, M.; Reese, S.

In Silico Reproduction of the Pathophysiology of In-Stent Restenosis Unveröffentlicht

2024.

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Danesini, Paolo Carlo; Heim, Maximilian; Tomalka, André; Siebert, Tobias; Ates, Filiz

Endomysium determines active and passive force production in muscle fibers Artikel

In: Journal of Biomechanics, Bd. Volume 168, Ausg. May 2024, 2024.

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Maier, Benjamin; Göddeke, Dominik; Huber, Felix; Klotz, Thomas; Röhrle, Oliver; Schulte, Miriam

OpenDiHu: An efficient and scalable framework for biophysical simulations of the neuromuscular system Artikel

In: Journal of Computational Science, Ausg. 79, S. 102291, 2024, ISBN: 1877-7503.

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Gaidzik, Franziska; Korte, Jana; Saalfeld, Sylvia; Janiga, Gabor; Berg, Philipp

Image-based Hemodynamic Simulations for Intracranial Aneurysms – The Impact of Complex Vasculatures Artikel

In: International Journal of Computer Assisted Radiology and Surgery, Bd. 19, Ausg. 4, S. 687-697, 2024.

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Homs-Pons, Carme; Lautenschlager, Robin; Schmid, Laura; Ernst, Jennifer; Göddeke, Dominik; Röhrle, Oliver; Schulte, Miriam

Coupled simulations and parameter inversion for neural system and electrophysiological muscle models Artikel

In: GAMM-Mitteilungen, 2024.

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Gerhäusser, Steffen; Lambers, Lena; Mandl, Luis; Franquinet, Julian; Ricken, Tim; König, Matthias

Simulation of zonation-function relationships in the liver using coupled multiscale models: Application to drug-induced liver injury Artikel

In: [PrePrint], bioRxiv, 2024.

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Stahl, Janneck; McGuire, Laura Stone; Rizko, Mark; Saalfeld, Sylvia; Berg, Philipp; Alaraj, Ali

Are hemodynamics responsible for inflammatory changes in venous vessel walls? A quantitative study of wall-enhancing intracranial arteriovenous malformation draining veins Artikel

In: Journal of Neurosurgery, 2024.

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Obermeier, Lukas; Wiegand, M.; Hellmeier, F.; Manini, C.; Kuehne, Titus; Goubergrits, Leonid

Verification Study of In Silico Computed Intracardiac Blood Flow With 4D Flow MRI Artikel

In: IEEE Transactions on Biomedical Engineering, Bd. 71, Ausg. 9, S. 2568 - 2579, 2024.

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Ates, Filiz; Roehrle, Oliver

Experiments meet simulations: Understanding skeletal muscle mechanics to address clinical problems Artikel

In: GAMM Mitteilungen, Bd. 2024, 2024.

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Schwarting, Julian; Holzberger, Fabian; Muhr, Markus; Renz, Martin; Boeckh-Behrens, Tobias; Wohlmuth, Barbara; Kirschke, Jan

Numerical simulation of individual coil placement – A proof-of-concept study for the prediction of recurrence after aneurysm coiling Artikel

In: [PrePrint], arXiv, 2024.

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Duswald, Tobias; Keith, Brendan; Lazarov, Boyan; Petrides, Socratis; Wohlmuth, Barbara

Finite elements for Matérn-type random fields: Uncertainty in computational mechanics and design optimization Artikel

In: [PrePrint], arXiv, 2024.

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Han, Mertcan; Yildiz, Erdost; Bozuyuk, Ugur; Aydin, Asli; Yu, Yan; Bhargava, Aarushi; Karaz, Selcan; Sitti, Metin

Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound Artikel

In: Nature Communications, Bd. 15, Ausg. 1, S. 2013, 2024.

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Lambers, Lena; Waschinsky, Navina; Schleicher, Jana; König, Matthias; Tautenhahn, Hans-Michael; Albadry, Mohamed; Dahmen, Uta; Ricken, Tim

Quantifying Fat Zonation in Liver Lobules: An Integrated Multiscale In-silico Model Combining Disturbed Microperfusion and Fat Metabolism via a Continuum-Biomechanical Bi-scale, Tri-phasic Approach Artikel

In: Biomechanics and Modeling in Mechanobiology, 2024.

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Thormann, Maximilian; Stahl, Janneck; Marsh, Laurel; Saalfeld, Sylvia; Sillis, Nele; Ding, Andreas; Mpotsaris, Anastasios; Berg, Philipp; Behme, Daniel

Computational Flow Diverter Implantation—A Comparative Study on Pre-Interventional Simulation and Post-Interventional Device Positioning for a Novel Blood Flow Modulator Artikel

In: Fluids, Bd. 9, Ausg. 3, Nr. 55, 2024.

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Villota-Narvaez, Yesid; Bleiler, Christian; Roehrle, Oliver

Data sharing in modeling and simulation of biomechanical systems in interdisciplinary environments Artikel

In: GAMM Mitteilungen, Bd. 47, Ausg. 2, 2024.

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Horvat, Medeea; Lunowa, Stephan B.; Sytnyk, Dmytro; Wohlmuth, Barbara

A lattice Boltzmann method for non-Newtonian blood flow in coiled intracranial aneurysms Artikel

In: [PrePrint], arXiv, 2024.

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Swiatek, Vanessa M; Amini, Amir; Ortuño, Celina E Sandalcioglu; Spitz, Lena; Hartmann, Karl; Rashidi, Ali; Stein, Klaus-Peter; Saalfeld, Sylvia; Sandalcioglu, I Erol; Neyazi, Belal

Unveiling rupture risk and clinical outcomes in midline aneurysms: A matched cohort analysis investigating the impact of localization within the anterior or posterior circulation Artikel

In: Neurosurgical Review, Bd. 47, Ausg. 76, 2024.

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Holzberger, Fabian; Muhr, Markus; Wohlmuth, Barbara

A Comprehensive Numerical Approach to Coil Placement in Cerebral Aneurysms: Mathematical Modeling and In Silico Occlusion Classification Artikel

In: [PrePrint], arXiv, 2024.

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Frank, Martin; Holzberger, Fabian; Horvat, Medeea; Kirschke, Jan; Mayr, Matthias; Muhr, Markus; Nebulishvili, Natalia; Popp, Alexander; Schwarting, Julian; Wohlmuth, Barbara

Numerical simulation of endovascular treatment options for cerebral aneurysms Artikel

In: [PrePrint], arXiv, 2024.

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König, Matthias

Python utilities for porous media analysis and visualization Online

Zenodo, (Hrsg.): 2024.

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Tautenhahn, Hans-Michael; Ricken, Tim; Dahmen, Uta; Mandl, Luis; Bütow, Laura; Gerhäusser, Steffen; Lambers, Lena; Chen, Xinpei; Lehmann, Elina; Dirsch, Olaf; König, Matthias

SimLivA–Modeling ischemia-reperfusion injury in the liver: A first step towards a clinical decision support tool Artikel

In: GAMM-Mitteilungen e202370003, 2024.

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Obermeier, Lukas; Korte, Jana; Vellguth, Katharina; Barbieri, Fabian; Hellmeier, Florian; Berg, Philipp; Goubergrits, Leonid

Inter-model and inter-modality analysis of left ventricular hemodynamics: comparative study of two CFD approaches based on TTE and MRI Artikel

In: GAMM-Mitteilungen, 2024.

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Schmid, Laura; Klotz, Thomas; Röhrle, Oliver; Powers, Randall K.; Negro, Francesco; Yavuz, Utku Ş.

Postinhibitory excitation in motoneurons Artikel

In: PLOS Computational Biology, Bd. 20, Ausg. 1, 2024.

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Korte, Jana; Marsh, Laurel M. M.; Saalfeld, Sylvia; Behme, Daniel; Aliseda, Alberto; Berg, Philipp

Fusiform versus Saccular Intracranial Aneurysms—Hemodynamic Evaluation of the Pre-Aneurysmal, Pathological, and Post-Interventional State Artikel

In: Journal of Clinical Medicine, Bd. 13, Ausg. 2, Nr. 551, S. 1-14, 2024.

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Ranno, A.; Manjunatha, K.; Glitz, A.; Schaaps, N.; Reese, S.; Vogt, F.; Behr, M.

In-silico Analysis of Hemodynamic Indicators in Idealized Stented Coronary Arteries for Varying Stent Indentation Unveröffentlicht

2024.

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Gerach, Tobias; Loewe, Axel

Differential effects of mechano-electric feedback mechanisms on whole-heart activation, repolarization, and tension Artikel

In: The Journal of Physiology, 2024.

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Korte, Jana; Klopp, Ehlar Sophie; Berg, Philipp

Multi-Dimensional Modeling of Cerebral Hemodynamics: A Systematic Review Artikel

In: Bioengineering, Bd. 11, Ausg. 1, S. 1-24, 2024.

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Fröhlich, Jonathan; Gerach, Tobias; Krauß, Jonathan; Loewe, Axel; Stengel, Laura; Wieners, Christian

Numerical evaluation of elasto-mechanical and visco-elastic electro-mechanical models of the human heart Artikel

In: GAMM Mitteilungen, Bd. 46, Ausg. 2, 2024, ISSN: 1522-2608.

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Yildiz, Erdost; Han, Mertcan; Werneck, Linda; Keip, Marc-Andre; Sitti, Metin; Ortiz, Michael

Experimental model for strain-induced mechanical neurostimulation on human progenitor neurons Artikel

In: Science Communications World Wide, 2024.

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2023

Gjerde, Ingeborg G.; Kuchta, Miroslav; Rognes, Marie E.; Wohlmuth, Barbara

Directional flow in perivascular networks: Mixed finite elements for reduced-dimensional models on graphs Artikel

In: [PrePrint], arXiv, 2023.

Abstract | Links | BibTeX

Albadry, Mohamed; Kuettner, Jonas; Grzegorzewski, Jan; Dirsch, Olaf; Kindler, Eva; Klopfleisch, Robert; Liska, Vaclav; Moulisova, Vladimira; Nickel, Sandra; Palek, Richard; Rosendorf, Jachym; Saalfeld, Sylvia; Settmacher, Utz; Tautenhahn, Hans-Michael; König, Matthias; Dahmen, Uta

Cross-Species Variability in Lobular Geometry and Cytochrome P450 Hepatic Zonation: Insights into CYP1A2, CYP2E1, CYP2D6 and CYP3A4 Artikel

In: [PrePrint], bioRxiv, 2023.

Abstract | Links | BibTeX

Holzberger, Fabian; Kirschke, Jan; Muhr, Markus; Nebulishvili, Natalia; Schwarting, Julian; Wohlmuth, Barbara

Breaking Blood Flow with Wires in Aneurysm Coiling Treatment Simulations Online

SIAM, News (Hrsg.): 2023, besucht am: 19.12.2023.

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Manjunatha, K.; Schaaps, N.; Behr, M.; Vogt, F.; Reese, S.

Computational Modeling of In-Stent Restenosis: Pharmacokinetic and Pharmacodynamic Evaluation Artikel

In: Computers in Biology and Medicine, Ausg. 167, 2023.

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Azhdari, Mohammad; Seyedpour, Seyed Morteza; Lambers, Lena; Tautenhahn, Hans-Michael; Tautenhahn, Franziska; Ricken, Tim; Rezazadeh, Ghader

Non-local three phase lag bio thermal modeling of skin tissue and experimental evaluation Artikel

In: Heat and Mass Transfer (149), 2023.

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Korte, Jana; Gaidzik, Franziska; Larsen, Naomi; Schütz, Erik; Damm, Timo; Wodarg, Fritz; Hövener, Jan-Bernd; Jansen, Olav; Janiga, Gábor; Berg, Philipp; Pravdivtseva, Mariya S

In vitro and in silico assessment of flow modulation after deploying the Contour Neurovascular System in intracranial aneurysm models Artikel

In: Journal of NeuroInterventional Surgery, 2023.

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Mandl, Luis; Mielke, André; Seyedpour, Seyed Morteza; Ricken, Tim

Affine transformations accelerate the training of physics-informed neural networks of a one-dimensional consolidation problem Artikel

In: Nature Scientific Reports, 2023.

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Stahl, Janneck; Kassem, Leheng; Behme, Daniel; Klebingat, Stefan; Saalfeld, Sylvia; Berg, Philipp

Fabrication of flexible intracranial aneurysm models using stereolithography 3D printing Artikel

In: Current Directions in Biomedical Engineering, Bd. 9, Ausg. 1, S. 395-389, 2023.

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Korte, Jana; Groschopp, Paula; Berg, Philipp

Resolution-based comparative analysis of 4D-phase-contrast magnetic resonance images and hemodynamic simulations of the aortic arch Artikel

In: Current Directions in Biomedical Engineering, Bd. 9, Ausg. 1, S. 650-653, 2023.

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Werneck, Linda; Han, Mertcan; Yildiz, Erdost; Keip, Marc-André; Sitti, Metin; Ortiz, Michael

A Simple Quantitative Model of Neuromodulation. Part I: Ion Flow Through Neural Ion Channels Artikel

In: Biological Physics, 2023.

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Sveric, Krunoslav Michael; Cansız, Barış; Winkler, Anna; Ulbrich, Stefan; Ende, Georg; Heidrich, Felix; Kaliske, Michael; Linke, Axel; Jellinghaus, Stefanie

Accuracy of Devereaux and Teichholz formulas for left ventricular mass calculation in different geometric patterns: comparison with cardiac magnetic resonance imaging Artikel

In: Scientific reports, Bd. 13, 2023.

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Korte, Jana; Voß, Samuel; Janiga, Gábor; Beuing, Oliver; Behme, Daniel; Saalfeld, Sylvia; Berg, Philipp

Is accurate lumen segmentation more important than outlet boundary condition in image-based blood flow simulations for intracranial aneurysms? Artikel

In: Cardiovascular Engineering and Technology, Bd. 14, Ausg. 5, S. 617–630, 2023.

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Maheshvare, M. Deepa; Raha, Soumyendu; König, Matthias; Pal, Debnath

A pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell Artikel

In: Frontiers in Endocrinology, 2023.

Abstract | Links | BibTeX

Cornelissen, A.; Florescu, R. A.; Reese, S.; Behr, M.; Ranno, A.; Manjunatha, K.; Schaaps, N.; Böhm, C.; Liehn, E. A.; Zhao, L.; Nilcham, P.; Milzi, A.; Schröder, J.; Vogt, F. J.

In-Vivo Assessment of Vascular Injury for the Prediction of In-Stent Restenosis Artikel

In: International Journal of Cardiology, Ausg. 388, 2023.

Abstract | Links | BibTeX

König, Matthias

Hepatocyte model of ischemia reperfusion injury (IRI) Online

Zenodo, (Hrsg.): 2023, besucht am: 30.06.2023.

Abstract | Links | BibTeX

Lee, Yongjae; Cansız, Barış; Kaliske, Michael

A multiphysical computational model of myocardial growth adopted to human pathological ventricular remodelling Artikel

In: 2023.

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Haggie, Lysea; Schmid, Laura; Röhrle, Oliver; Besier, Thor; McMorland, Angus; Saini, Harnoor

Linking cortex and contraction—Integrating models along the corticomuscular pathway Artikel

In: Frontiers in Physiology, Sec. Computational Physiology and Medicine, Ausg. Vol 14-2023, 2023.

Abstract | Links | BibTeX

Simeon, Bernd

Die Macht der Computermodelle. Quellen der Erkenntnis oder digitale Orakel? Buch

1, Springer Berlin, Heidelberg, 2023, ISBN: 978-3-662-66298-4.

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Stahl, Janneck; Marsh, Laurel Morgan Miller; Thormann, Maximilian; Ding, Andreas; Saalfeld, Sylvia; Behme, Daniel; Berg, Philipp

Assessment of the Flow-Diverter Efficacy for Intracranial Aneurysm Treatment Considering Pre- and Post-Interventional Hemodynamics Artikel

In: Computers in Biology and Medicine, Bd. 156, Ausg. 106720, 2023.

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94 Einträge « 1 von 2 »