Skalenübergreifende Kopplung vaskulärer Hämodynamik zur KI-basierten, standardisierten Evaluation neurologischer Pathologien

@article{10.1136/bmjopen-2022-063051,

title = {Geometric uncertainty in intracranial aneurysm rupture status discrimination: a two-site retrospective study },

author = {Florian Hellmeier and Jan Bruening and Philipp Berg and Sylvia Saalfeld and Andreas Spuler and Erol I. Sandalcioglu and Oliver Beuing and Naomi Larsen and Jens Schaller and Leonid Goubergrits},

editor = {BMJ Open},

url = {https://pubmed.ncbi.nlm.nih.gov/36351732/},

doi = {10.1136/bmjopen-2022-063051 },

year  = {2022},

date = {2022-11-08},

urldate = {2022-11-08},

journal = {BMJ Open},

volume = {12},

issue = {11},

abstract = {Assessing the risk associated with unruptured intracranial aneurysms (IAs) is essential in clinical decision making. Several geometric risk parameters have been proposed for this purpose. However, performance of these parameters has been inconsistent. This study evaluates the performance and robustness of geometric risk parameters on two datasets and compare it to the uncertainty inherent in assessing these parameters and quantifies interparameter correlations. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{https://doi.org/10.1515/cdbme-2022-0004,

title = {Centerline and blockstructure for faststructured mesh generation},

author = {Annika Niemann and Gabor Janiga and Bernhard Preim and Daniel Behme and Sylvia Saalfeld},

editor = {De Gruyter},

url = {https://www.degruyter.com/document/doi/10.1515/cdbme-2022-0004/html},

doi = {https://doi.org/10.1515/cdbme-2022-0004},

year  = {2022},

date = {2022-07-30},

urldate = {2022-07-30},

journal = {Current Directions in Biomedical Engineering},

abstract = {In contrast to unstructured meshes, structured meshes yield faster simulation results for bio-medical simulations, but are very time-consuming to create. A preprocessing step in the generation of structured meshes is the manual construction of a block structure approximating the vessel. Here, we present an automatic centreline calculation and blockstructure generation to reduce the user effort and time of structured mesh generation. The center line is detected as points in between opposite faces. Based on the centerline, cross sections are determined and a blockstructure which approximates the vessel is automatically generated. The centreline detection does not require time-consuming user input and meshes with more than 195,000 vertices are processed in less than 160 seconds. The results of the presented automatic centreline detection are compared to a centreline with manual input generated by the widely used vmtk tool. The centerlines are similar, small differences occur at bifurcation and at the aneurysm.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{https://doi.org/10.1515/cdbme-2022-0032,

title = {Impact of patient-specific inflow boundary conditions on intracranial aneurysm hemodynamics},

author = {Janneck Stahl and Anna Bernovskis and Daniel Behme and Sylvia Saalfeld and Philipp Berg },

editor = {De Gruyter},

url = {https://www.degruyter.com/document/doi/10.1515/cdbme-2022-0032/html},

doi = {https://doi.org/10.1515/cdbme-2022-0032},

year  = {2022},

date = {2022-07-30},

urldate = {2022-07-30},

journal = {Current Directions in Biomedical Engineering},

volume = {8},

issue = {1},

pages = {125-128},

abstract = {For hemodynamic simulations of intracranial aneurysms boundary conditions (BC) are required. In most cases, these are not patient-specific and thus do not reflect the real flow conditions in the patient. This study investigates the influence of patient-specific inflow BC on intra-aneurysmal hemodynamics. The focus lies on gender and age variations of the patients. To asses the impact, four different inflow curves representing the velocity profile of the inflow over one cardiac cycle is modeled. These four inflow BC are varied in the simulations of each aneurysm from selected subgroups. From the results of the simulations, the hemodynamic parameters are determined for each inflow BC and the percent differences between inflow BC are determined. The results show that the hemodynamic parameters are not  obust to varying inflow BC. It can be seen that age has more influence on the hemodynamic parameters than gender. This study demonstrates the dependence of valid hemodynamic parameters on realistic inflow BC. Thus, if available, patient-specific inflow curves are recommended.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{https://doi.org/10.1515/cdbme-2022-0033,

title = {Segmentation of Circle of Willis from 7T TOF-MRI data and immersive exploration using VR},

author = {Lena Spitz and Mareen Allgaier and Anastasios Mpotsaris and Daniel Behme and Bernhard Preim and Sylvia Saalfeld },

editor = {De Gruyter},

url = {https://www.degruyter.com/document/doi/10.1515/cdbme-2022-0033/html},

doi = {https://doi.org/10.1515/cdbme-2022-0033},

year  = {2022},

date = {2022-07-30},

urldate = {2022-07-30},

journal = {Current Directions in Biomedical Engineering},

volume = {8},

issue = {1},

pages = {129-132},

abstract = {7T TOF MRI scans provide high resolution images of intracranial vasculature. When segmented, the Circle of Willis is detailed and thus opens up new possibilities, in research but also in education. We propose a segmentation pipeline for the Circle ofWillis, and introduce a prototype that enables exploration of not just the entire Circle of Willis, but also of its centerline, in an immersive VR enviroment. In our prototype, the model can be freely rotated, placed and scaled. A qualitative evaluation was performed with two experienced neuroradiologists, who rated the prototype and its potential positively.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{https://doi.org/10.3389/fneur.2021.771694,

title = {Can Endovascular Treatment of Fusiform Intracranial Aneurysms Restore the Healthy Hemodynamic Environment? - A Virtual Pilot Study},

author = {Sylvia Saalfeld and Janneck Stahl and Jana Korte and Laurel M. Miller Marsh and Bernhard Preim and Oliver Beuing and Yurii Cherednychenko and Daniel Behme and Philipp Berg },

url = {https://www.frontiersin.org/articles/10.3389/fneur.2021.771694/full},

doi = {https://doi.org/10.3389/fneur.2021.771694},

year  = {2022},

date = {2022-01-24},

urldate = {2022-01-24},

journal = {Frontiers},

volume = {Volume 12 - 2021},

abstract = {Numerous studies assess intracranial aneurysm rupture risk based on morphological and hemodynamic parameter analysis in addition to clinical information such as aneurysm localization, age, and sex. However, intracranial aneurysms mostly occur with a saccular shape located either lateral to the parent artery or at a bifurcation. In contrast, fusiform intracranial aneurysms (FIAs), i.e., aneurysms with a non-saccular, dilated form, occur in approximately 3–13% of all cases and therefore have not yet been as thoroughly studied. To improve the understanding of FIA hemodynamics, this pilot study contains morphological analyses and image-based blood flow simulations in three patient-specific cases. For a precise and realistic comparison to the pre-pathological state, each dilation was manually removed and the time-dependent blood flow simulations were repeated. Additionally, a validated fast virtual stenting approach was applied to evaluate the effect of virtual endovascular flow-diverter deployment focusing on relevant hemodynamic quantities. For two of the three patients, post-interventional information was available and included in the analysis. The results of this numerical pilot study indicate that complex flow structures, i.e., helical flow phenomena and the presence of high oscillating flow features, predominantly occur in FIAs with morphologically differing appearances. Due to the investigation of the individual healthy states, the original flow environment could be restored which serves as a reference for the virtual treatment target. It was shown that the realistic deployment led to a considerable stabilization of the individual hemodynamics in all cases. Furthermore, a quantification of the stent-induced therapy effect became feasible for the treating physician. The results of the morphological and hemodynamic analyses in this pilot study show that virtual stenting can be used in FIAs to quantify the effect of the planned endovascular treatment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}